Polygenic prediction of keratoconus and its measures: cross-sectional and longitudinal analyses in community-based young adults
A genetic risk score to predict the development and progression of keratoconus, was developed by a team of researchers from QIMR Berghofer Medical Research Institute and The University of Western Australia. By analysing data from young adults, the team found that higher scores indicate a greater risk of developing the disease and worse outcomes for those already affected. These findings could help doctors identify at-risk individuals early, guiding interventions to prevent severe complications.
The Supercomputer, SETONIX, provided computation resources to process and analyse large amounts of genetic and imaging data. The team, including Santiago Diaz Torres, Weixiong He, Puya Gharahkhani, Stuart MacGregor, Samantha Sze-Yee Lee, Seyhan Yazar, Gareth Lingham and David A. Mackey used data from two major community-based studies: The Raine Study and The Kidskin Young Adult Myopia Study (KYAMS). The data from these studies has been instrumental in shaping our understanding of health and genetics, offering valuable insights into the factors influencing health and disease.
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